Karla Brammer ran her fourth marathon this year, the Chicago Marathon, and she’s well acquainted with the injuries that can result.
To help orthopedics patients regain mobility faster, Karla is redesigning the surface of bone implants, looking at their nanostructures to enhance their integration into the body and accelerate bone growth. Currently, titanium implants – like those used in hip replacements – have a layer of titanium oxide (TiO2) on the surface which allows the implant and bone to bond better than most other metals.
Karla’s research focuses on improving the topographic structure of this layer to enhance the “osseo-integration” properties (where implants attach directly to the bone), advance healing, and boost implant performance. Others in her field have chosen to incorporate bone mineral-based coatings, attempting to improve integration, however foreign layers tend to delaminate and cause implant failure. By reconstructing the surface of the titanium implant rather than adding a foreign layer, Karla is able to gain precise control on the nanolevel and use microscopic clues to see how the bone will react to the implant. With the resultant accelerated bone growth Karla hopes to obtain, patients would recover from surgery much more quickly and could begin walking after one month, one-third the time it takes currently.
After she completes her Ph.D. in Bioengineering at UC San Diego, Karla hopes to join a local medical device company. She’s fascinated by nanotechnology, also applying her materials science and nanogeometry approach to stem cell therapies, but prefers to be “on the hook” to build actual products for the market.
Karla received her Bachelor’s degree in Materials Science and Engineering from Ohio State University. Born and raised in Ohio, she is a passionate Buckeyes fan and remains actively involved in her alumni association.